This Clinical Guidance (“Guidance”) is provided for informational and educational purposes only. It is intended to offer healthcare providers guidance on best practices for the care and treatment of patients infected with mpox in 2024. Adherence to any recommendations included in this Guidance does not guarantee successful outcomes in every case. Furthermore, the recommendations contained herein should not be construed as establishing a standard of care, nor should they be considered exhaustive of all appropriate methods of care or exclusive of other valid approaches.